Galmed Pharmaceuticals 與 Barcode 合作開發心臟靶向 LNP 製劑，推動 Aramchol 進軍心臟纖維化領域

EX-99.1
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EX-99.1

 

 

Exhibit 99.1

 

Galmed
Announces the Breakthrough Development of Novel LNP Cardiac Targeted Formulation of its SCD1 inhibitor, Aramchol

 

 
  
 ●
 Galmed has
 developed, in collaboration with Barcode Nanotech, a unique proprietary lipid nanoparticles (LPNs) novel formulation of Aramchol
 that penetrates the heart tissue and redirects Aramchol’s biodistribution away from liver-hepatocytes to the heart’s
 muscle.

 
  
 ●
 Cardiac fibrosis is a major
 driver of chronic heart failure, the leading cause of death globally, responsible for an estimated 20.5 million deaths in 2025.

 
  
 ●
 Aramchol’s anti-fibrotic
 effects were demonstrated in the liver in a Phase 3 (open label part) MASH study as well as in human heart organoids and in-vivo
 lung and heart models.

 
  
 ●
 Traditional Aramchol formulation
 results in 80-90% accumulation in the liver and has limited effect on the heart. The new LPNs Aramchol formulation which selectively
 targets the heart tissue could potentially become a disease modifying therapy for cardiac fibrosis and unmet cardiac diseases.

 
 

Ramat-Gan,
Israel, July 16, 2026 /PRNewswire/ — Galmed Pharmaceuticals Ltd. (NASDAQ: GLMD) (“Galmed” or the “Company”),
a clinical-stage biopharmaceutical company focused on liver, cardiometabolic and GI oncology diseases, today announced the breakthrough
development of a new Aramchol-based lipid nanoparticles formulation (LNP) for targeted delivery to the heart.

 

Further
advancing the previously reported development of Aramchol’s nanocarrier-enabled targeted formulations), Galmed has developed
a novel LNP formulation of Aramchol, based on FDA approved lipids, that penetrates the heart tissue.

 

The
development work, a collaboration between Galmed and Barcode Nanotech, applies advanced formulation science, in vivo screening, and AI-enabled
analysis which aims to identify optimal vehicles for precise cardiac delivery. The platform enables in vivo screening of hundreds of
nanoparticle candidates to support the identification of formulations with potentially improved targeting, biodistribution, and functional
performance. By adapting this platform to cardiac applications, the companies aim to develop cardiac-targeted therapies delivered through
LNPs that can selectively engage relevant cell populations, including fibroblasts and other disease-driving cardiac cells. These efforts
are intended to support both Aramchol-based cardiac programs and future therapeutic candidates built on the same delivery technology.

 

Cardiac
fibrosis is a major contributor to heart failure progression and remains an area of significant unmet medical need. Despite advances
in cardiovascular care, no therapies directly prevent or reverse cardiac fibrosis, highlighting the need for novel therapeutic approaches.
The goal of the Galmed – Barcode collaboration is to open a new route for disease-modifying therapies in cardiovascular medicine,
where efficient and selective delivery to the heart tissue remains a major challenge.

 

  

  

 

 

Allen
Baharaff, Galmed’s Co-founder and CEO, commented: “Galmed remains focused on developing transformative medicines and technologies
in the GI space. Our present efforts are addressed to the commercialization of CG-100, the technology developed by the recently
acquired Colospan and clinical development of Aramchol for GI oncology indications. The collaboration with Barcode Nanotech supports
a longer-term vision of advancing Aramchol in new formulations and discovering cutting edge therapies for cardiometabolic diseases, based
on the core competences of both companies. This has the potential to position Galmed at the forefront of drug development innovation
and open the door for future partnerships”.

 

Ronen
Eavri, Co-founder & CEO of Barcode Nanotech, commented: “Barcode Nanotech has developed a library of novel lipids for RNA and
DNA, LNP-based delivery, through a unique in vivo & AI-based screening platform which allow simultaneously screening of hundreds
of different nanoparticle formulations. Our proprietary lipid library and screening platform capabilities enable the development of Aramchol’s
selective delivery LNP formulation to the heart. We now focus on the development of modified LNPs to target specific cardiac cell types.
We believe this work may create the basis for a new generation of cardiac therapies, with Aramchol serving as an important first example
of what our platform can achieve.”

 

About
Galmed Pharmaceuticals Ltd.:

 

Galmed
Pharmaceuticals Ltd. is a biopharmaceutical and medical device company focused on developing innovative solutions for gastrointestinal,
cardiometabolic and oncology indications. The Company is advancing Aramchol and related product candidates for GI oncology and other
potential indications, while also exploring novel targeted delivery technologies and therapeutic approaches for cardiometabolic diseases.
In addition, through its wholly owned subsidiary, Colospan Ltd., the Company is developing and commercializing CG-100, a medical device
designed to address complications associated with colorectal surgery. Galmed’s strategy is to build a diversified platform that
leverages its expertise in drug development, medical devices and gastrointestinal disease to address significant unmet medical needs.

 

About
Barcode Nanotech Ltd.:

 

Barcode
Nanotech develops delivery solutions for RNA & DNA therapies through a unique multiplexed discovery platform. The Company’s
proprietary NeoRNATM Targeting Technology enables efficient discovery and optimization of lipid-based nanoparticles (LNPs)
through in silico & in vivo mass-screening. The solution combines the design of thousands of new lipids and LNPs, advanced
AI tools and in vivo barcoding-based biodistribution analysis at a single cell resolution. Using this platform, Barcode has developed
unique LNPs that can direct RNA and other therapies to cells in the brain, kidney, lungs and additional target organs. The company has
an in-house lead drug development program and concurrently collaborates with biopharma companies to develop new therapies.

 

  

  

 

 

Forward-Looking
Statements:

 

Forward-looking
statements relate to anticipated or expected events, activities, trends or results as of the date they are made. Because forward-looking
statements relate to matters that have not yet occurred, these statements are inherently subject to risks and uncertainties that could
cause our actual results to differ materially from any future results expressed or implied by the forward-looking statements. Forward-looking
statements may include, but are not limited to, statements relating to the potential of the collaboration between the Company and Barcode
Nanotech and the novel formulation of Aramchol. Many factors could cause our actual activities or results to differ materially from the
activities and results anticipated in forward-looking statements, including, but not limited to, our inability to recognize the anticipated
benefits of the acquisition of Colospan; expectations with respect to future performance and growth of Colospan; the development and
approval of the use of Aramchol or any other product candidate for indications outside of non-alcoholic steatohepatitis, or NASH, also
known as metabolic dysfunction-associated steatohepatitis, or MASH, and fibrosis or in combination therapy; the timing and cost of any
pre-clinical or clinical trials of CG-100, Aramchol or any other medical device or product candidate we develop; completion and receiving
favorable results of any pre-clinical or clinical trial; regulatory action with respect to CG-100, Aramchol or any other medical device
or product candidate by the U.S. Food and Drug Administration, or the FDA, or the European Medicines Authority, or EMA, including but
not limited to acceptance of an application for marketing authorization, review and approval of such application, and, if approved, the
scope of the approved indication and labeling; the commercial launch and future sales of CG-100, Aramchol and any future medical devices
or product candidates; our ability to comply with all applicable post-market regulatory requirements for CG-100, Aramchol, or any other
medical device or product candidate in the countries in which we seek to market the product; our ability to achieve favorable pricing
for CG-100, Aramchol, or any medical device or other product candidate; third-party payor reimbursement for CG-100, Aramchol, or any
other medical device or product candidate; our estimates regarding anticipated capital requirements and our needs for additional financing;
market adoption of CG-100 Aramchol or any other medical device or product candidate by physicians and patients; the timing, cost or other
aspects of the commercial launch of CG-100, Aramchol or any other medical device or product candidate; our ability to obtain and maintain
adequate protection of our intellectual property; the possibility that we may face third-party claims of intellectual property infringement;
our ability to manufacture our CG-100 or product candidates in commercial quantities, at an adequate quality or at an acceptable cost;
our ability to establish adequate sales, marketing and distribution channels; intense competition in our industry, with competitors having
substantially greater financial, technological, research and development, regulatory and clinical, manufacturing, marketing and sales,
distribution and personnel resources than we do; our expectations regarding licensing, acquisitions and strategic operations; current
or future unfavorable economic and market conditions and adverse developments with respect to financial institutions and associated liquidity
risk; our ability to maintain the listing of our ordinary shares on The Nasdaq Capital Market; and the security, political and economic
instability in the Middle East that could harm our business, including due to the current security situation in Israel. We believe these
forward-looking statements are reasonable; however, these statements are only current predictions and are subject to known and unknown
risks, uncertainties and other factors that may cause our or our industry’s actual results, levels of activity, performance or
achievements to be materially different from those anticipated by the forward-looking statements. We discuss many of these risks in our
Annual Report on Form 20-F for the year ended December 31, 2025, filed with the SEC on March 31, 2026 in greater detail under the heading
“Risk Factors.” Given these uncertainties, you should not rely upon forward-looking statements as predictions of future events.
All forward-looking statements attributable to us or persons acting on our behalf speak only as of the date hereof and are expressly
qualified in their entirety by the cautionary statements included in this report. We undertake no obligations to update or revise forward-looking
statements to reflect events or circumstances that arise after the date made or to reflect the occurrence of unanticipated events. In
evaluating forward-looking statements, you should consider these risks and uncertainties.

 

Investor
and Media contact:

 

Guy
Nehemya, +972-3-693-8448, [email protected]